Article
  • Evaluation of Freeze-Dry Chitosan-Gelatin Scaffolds with Olibanum Microspheres Containing Dexamethasone for Bone Tissue Engineering

  • Parastoo Namdarian, Ali Zamanian*,† , Azadeh Asefnejad, and Maryam Saeidifar**

  • Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
    *Biomaterials Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Tehran, Iran
    **Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Tehran, Iran

  • 덱사메타손을 담지한 올리바넘 미립자 함유 키토산-젤라틴 동결건조 지지체의 골조직공학 응용
Abstract

Bone tissue engineering is now used as an alternative for the treatment of bone-related diseases. In this study, chitosan-gelatin scaffold with olibanum microspheres containing dexamethasone has been produced by the freeze-drying method. SEM and FTIR were used to characterize the scaffolds synthesized. The rate of drug release from these scaffolds was measured by a UV spectrophotometer. The synthesized scaffold was measured in terms of the swelling and degradation rates. In vitro studies were conducted to evaluate bioactivity and the environmental compatibility of the scaffold with an MTT test. A good controlled release was achieved. The bioactivity analysis confirmed the formation of apatite. The results of the MTT test showed that the synthesized scaffold was biocompatible and had an appropriate interaction with the cell. The results showed that the produced scaffold had the properties necessary to regenerate and repair bones.


Keywords: Olibanum, microsphere, scaffold, freeze-drying, dexamethasone

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2018; 42(6): 982-993

    Published online Nov 25, 2018

  • 10.7317/pk.2018.42.6.982
  • Received on May 11, 2018
  • Revised on Jun 15, 2018
  • Accepted on Jul 17, 2018

Correspondence to

  • Ali Zamanian*

  • *Biomaterials Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Tehran, Iran

  • E-mail: a-zamanian@merc.ac.ir