Article
  • Effect of pH on the Accelerated Aging Test of Gastrointestinal Absorption Inhibiting Stent Materials

  • Bong Seok Jang*,**, Ja Young Cheon*, Min Young Jung**,† , Oh Hyeong Kwon***, and Won Ho Park*,†

  • *Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea
    **R&D Institute of Intervention, M. I. Tech Co., Ltd., Pyeongtaek 17711, Korea
    ***Departement of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177 Korea

  • 위장관 흡수 억제용 스텐트 재료의 가속 노화시험에 대한 pH의 영향

  • 장봉석*,** · 천자영* · 정민영**,† · 권오형*** · 박원호*,†

  • *충남대학교 유기소재섬유시스템공학과, **㈜엠아이텍, ***금오공과대학교 고분자공학과

Abstract

The stability of silicone and fluoropolymer materials, such as expanded polytetrafluoroethylene (e-PTFE) and fluorinated ethylene propylene copolymer (FEP), was assessed as bypass liners of an absorption inhibition stent to treat obesity. The stability was evaluated by conducting an accelerated aging test in a pH condition similar to a stomach acid and bile acid environments in contact with the actual stent bypass liner. The changes in the morphology and properties (chemical and physical) after accelerated aging were analyzed via SEM, FTIR and UTM. In addition, a bile acid permeation experiment was carried out using e-PTFE to confirm that in vitro testing could be used as a bypass liner of the stent to treat obesity.


연신 polytetrafluoroethylene(e-PTFE) 및 fluorinated ethylene propylene copolymer(FEP)와 같은 불소계 고분자와 실리콘 재료의 안정성을 비만 치료용 흡수 억제 스텐트의 바이패스 라이너로 평가하였다. 안정성 평가는 실제 스텐트의 바이패스 라이너가 접촉하는 위산과 담즙산 환경과 유사한 pH 조건에서 가속 노화실험을 통해 이루어졌다. 가속 노화실험 전후의 형태학적, 물리·화학적 변화는 주사전자현미경, 적외선분광분석, 인장시험 등을 통해서 확인하였다. 또한 담즙산 투과실험은 in vitro 시험이 비만 치료용 스텐트의 바이패스 라이너로 유용한지를 확인하기 위해 e-PTFE 시료를 사용하여 수행되었다.


Keywords: bypass liner stent, silicone, expanded poly(tetrafluoroethylene), fluorinated ethylene propylene copolymer, accelerated aging test

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2019; 43(2): 261-267

    Published online Mar 25, 2019

  • 10.7317/pk.2019.43.2.261
  • Received on Nov 14, 2018
  • Revised on Nov 26, 2018
  • Accepted on Nov 29, 2018

Correspondence to

  • Min Young Jung**, and Won Ho Park*

  • *Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea
    **R&D Institute of Intervention, M. I. Tech Co., Ltd., Pyeongtaek 17711, Korea

  • E-mail: myjung@mitech.co.kr, parkwh@cnu.ac.kr