Article
  • Gelation Behavior and Self-healing Property of Glycol Chitosan with Catechol Functionality
  • So Yun Jeong, Eunu Kim, and Won Ho Park

  • Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, Korea

  • 카테콜기로 치환된 글리콜 키토산의 젤화거동 및 자가치유능
  • 정소윤 · 김은우 · 박원호

  • 충남대학교 유기재료공학과

Abstract

Glycol chitosan (GC) is a hydrophilic derivative of chitosan, and has non-toxic, biocompatible, and biodegradable properties. Also, GC shows excellent solubility under a wide range of pH conditions. Therefore, it is widely studied in various biomedical fields due to the excellent solubility. The self-healing hydrogel means that the hydrogel could restore its structure and functionality after damage. This self-healing behavior can be achieved by the dynamic chemical bonds including imine bond as well as the physical bonds including hydrogen bond, and can be applicable to scaffolds for tissue engineering and drug delivery systems. In this study, the catechol-modified GC (GC-CA) conjugate was synthesized, and its self-healing hydrogel was prepared via Schiff’s base (-CH=N-) formation of GC-CA conjugate. The gelation behavior and self-healing properties of the GC-CA hydrogel were dependent on the various conditions, such as polymer concentration, degree of substitution, and pH. The results indicate that the GC-CA hydrogel will be applicable to self-healing biomaterials and tissue engineering scaffolds


글리콜 키토산은 키토산의 친수성 유도체로서 무독성, 생체적합성 및 생분해성을 가지며, 넓은 범위의 pH 조건의 수용액에서 우수한 용해성을 나타내는 친수성 다당류이다. 따라서 글리콜 키토산은 키토산과는 달리 중성 pH 조건의 수용액에서 용해가 가능하기 때문에 생체재료 분야에서 연구가 활발히 진행되고 있다. 한편, 자가치유 수화젤은 외력에 의해 파괴된 가교구조를 원래대로 회복할 수 있는 능력을 가진 수화젤을 의미한다. 이는 수소결합과 같은 물리적 결합 혹은 이민결합과 같은 화학적 결합을 통해 제조할 수 있으며, 조직공학용 재료 및 약물전달시스템 등에서 응용되고 있다. 본 연구에서는 이민결합 형성을 위해 글리콜 키토산에 카테콜기를 도입하여 자가치유 특성을 가지는 수화젤을 제조하였다. 또한 농도, 치환도 및 pH에 따른 젤화거동의 변화와 자가치유능을 분석하여 생체재료로서의 적용가능성을 살펴보았다


Keywords: glycol chitosan, hydrogel, self-healing, imine bond, catechol group

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2020; 44(2): 225-232

    Published online Mar 25, 2020

  • 10.7317/pk.2020.44.2.225
  • Received on Jan 13, 2020
  • Revised on Feb 13, 2020
  • Accepted on Feb 14, 2020

Correspondence to

  • Won Ho Park
  • Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, Korea

  • E-mail: parkwh@cnu.ac.kr