Article
  • Drug Delivery Behavior of PCL and PCL/PEG Microcapsules Prepared by High-speed Agitator and Syringe Pump
  • Hyunju Lim, Ji-Yeon Shin, Deuk Yong Lee , Bae-Yeon Kim*, and Yo-Seung Song**

  • Department of Biomedical Engineering, Daelim University, Anyang 13916, Korea
    *Department of Materials Science and Engineering, Incheon National University, Incheon 22012, Korea
    **Department of Materials Engineering, Korea Aerospace University, Goyang 10540, Korea

  • 고속교반기와 주사기 펌프로 제조한 PCL과 PCL/PEG 마이크로캡슐의 약물방출거동
  • 임현주 · 신지연 · 이득용 · 김배연* · 송요승**

  • 대림대학교 의공융합과, *인천대학교 신소재공학과, **한국항공대학교 재료공학과

Abstract

Nifedipine (NF)-loaded PCL and PCL/PEG microcapsules with diameters ranging from 1 to 5 µm are synthesized by the oil-in-water emulsion-solvent evaporation technique to evaluate the influence of stirring speed, PCL concentration, and PCL/PEG weight ratio on morphology and drug delivery behavior of the capsules. The size of PCL capsules decreased as the PCL concentration decreased from 8 to 2 wt% and the stirring speed increased from 3000 to 5000 rpm. The diameter of PCL/PEG capsules increased by varying the PCL/PEG ratio from 10/0 to 6/4. Higher amount of released NF is observed for smaller PCL capsules and larger PCL/PEG capsules, respectively. FTIR results revealed that the NF-loaded PCL and PCL/PEG capsules were formed due to hydrogen bonding between PCL and NF. The capsules showed no evidence of cytotoxicity, suggesting that the capsules were safe.


1~5 μm 직경을 가진 니페디핀(NF)을 함유하는 폴리카프로락톤(PCL)과 PCL/폴리에틸렌 글리콜(PEG) 마이크로캡슐을 고속교반기를 이용하여 액중건조법으로 제조하여 교반속도, PCL 농도, PCL/PEG 중량비에 따른 캡슐의 형상과 약물전달거동을 조사하였다. PCL 농도가 8에서 2 wt%로 감소하고, 교반속도가 3000에서 5000 rpm로 증가함에 따라 캡슐크기는 감소하였다. 반면에, PCL/PEG 캡슐의 크기는 PCL/PEG 비가 10/0에서 6/4로 변화함에 따라 증가하였다. 직경이 작은 PCL 캡슐과 큰 PCL/PEG 캡슐에서 많은 양의 NF가 관찰되었다. FTIR 관찰결과, NF의 카보닐기와 아민기에 의해 PCL과 NF가 성공적으로 결합되어 있었다. 세포독성 실험결과, PCL과 PCL/PEG 캡슐은 세포 용해나 독성이 없어 안전하였다.


Keywords: poly(e-caprolactone) (PCL), poly(ethylene glycol) (PEG), nifedipine, microcapsule, drug release

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2018 Impact Factor : 0.500
  • Indexed in SCIE

This Article

  • 2020; 44(4): 487-494

    Published online Jul 25, 2020

  • 10.7317/pk.2020.44.4.487
  • Received on Feb 27, 2020
  • Revised on Apr 4, 2020
  • Accepted on Apr 13, 2020

Correspondence to

  • Deuk Yong Lee
  • Department of Biomedical Engineering, Daelim University, Anyang 13916, Korea

  • E-mail: duke1208@gmail.com