Article
  • Synthesis and Characterization of Gallic Acid Conjugated Glycol Chitosans for Tissue Adhesive Applications

  • Seul Gi Park# , Mei-Xian Li*, **,#, Ji Hwan Eom***, Eun Yeong Suh, Woo Kyung Cho***,† , Yoon Ki Joung**,† , and Kang Moo Huh†

  • Departments of Polymer Science and Engineering & Chemical Engineering and Applied Chemistry,
    Chungnam National University, 99 Daehakro, Yuseonggu, Daejeon 34134, Korea
    *School of Textile and Clothing, Nantong University, Nantong 226019, China
    **Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea
    ***Department of Chemistry, Chungnam National University, 99 Daehakro, Yuseonggu, Daejeon 34134, Korea

  • 조직접착성 소재로서의 갈릭산 함유 글리콜 키토산 유도체의 제조 및 특성 평가

  • 박슬기# · 이미현*, **,# · 엄지환*** · 서은영 · 조우경***,† · 정윤기**,† · 허강무†

  • 충남대학교 고분자공학과, *난통대학교 방직의류학과, **한국과학기술연구원, ***충남대학교 화학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

In this study, we developed self-crosslinkable and self-healing hydrogels by conjugating biocompatible and biodegradable glycol chitosan (GC) with biofunctional gallic acid (GA) and evaluated their potential application as a new tissue adhesive biomaterial. A series of GA-GC derivatives with different GA content were synthesized by varying the feed molar ratio of GA and their hydrogels were prepared via self-crosslinking reaction between pyrogallol groups of GA. The self-healing ability of GA-GC hydrogels was confirmed by rheological analysis, and their mechanical strength and tissue adhesion strength were observed to increase as the GA content of the hydrogels increased. The GA-GC hydrogels with biodegradability and low cytotoxicity would be useful as new tissue adhesive biomaterials


본 연구에서는 생체적합성이 우수한 글리콜 키토산에 생기능성 분자인 갈릭산(GA)을 화학적으로 결합하고, 자가-가교(self-crosslinking) 및 자가-치유(self-healing)가 가능한 갈릭산 함유 글리콜 키토산(GA-GC) 하이드로젤을 제조하였으며, 조직접착성 소재로의 응용 가능성을 평가하였다. GA의 반응 몰비를 조절하여 GA 함량이 서로 다른 일련의 GA-GC 유도체들을 합성하고, GA의 파이로갈롤기에 의한 자가-가교 반응을 통해 하이드로젤을 제조하였다. GA-GC 하이드로젤의 자가-치유 능력을 점탄성 분석을 통해 확인하였고, 하이드로젤의 GA 함량이 증가됨에 따라 압축강도와 조직 접착강도가 증가하는 것을 관찰하였다. 생분해성과 낮은 세포독성을 보임으로써 GA-GC 하이드로젤은 조직접착성 생체재료로 유용하게 응용될 수 있을 것으로 기대된다


Keywords: glycol chitosan, gallic acid, tissue adhesive application, hydrogel, self-crosslinking, self-healing

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2021; 45(3): 372-379

    Published online May 25, 2021

  • 10.7317/pk.2021.45.3.372
  • Received on Nov 12, 2020
  • Revised on Jan 16, 2021
  • Accepted on Jan 18, 2021

Correspondence to

  • Woo Kyung Cho***, Yoon Ki Joung**, and Kang Moo Huh†

  • Departments of Polymer Science and Engineering & Chemical Engineering and Applied Chemistry,
    Chungnam National University, 99 Daehakro, Yuseonggu, Daejeon 34134, Korea
    **Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea
    ***Department of Chemistry, Chungnam National University, 99 Daehakro, Yuseonggu, Daejeon 34134, Korea

  • E-mail: wkcho@cnu.ac.kr, ykjoung@kist.re.kr, khuh@cnu.ac.kr