Article
  • Synthesis and Properties of Polymeric Skin Substitute ( I ) Evaluation of Bilayer Membrane Composed of Crosslinked Gelatin and Polyurethane
  • Kim KY, Min DS, Chun HJ
  • 고분자 인공피부의 합성과 성질(Ⅰ) 가교젤라틴과 폴리우레탄으로 된 복합막의 평가
  • 김계용, 민동선, 전홍재
Abstract
The bilayer membrane which comprises a upperlayer of a medical grade polyurethane and a underlayer of a porous corsslinked network of gelatin and poly(vinyl alcohol ) was prepared. Possibilities of the membrane for the usuage as skin substitute were estimated by measuring tensile strength and elongation under dry or wet condition and biodegradation ratio, and also studied by permeabilities of water vapor and oxygen. The degree of swelling was decreased with increasing the concentration of closslinking agent. And the tensile strength was increased with increasing the concentration of crosslinking agent, from 500kg/cm2 to 720kg/cm2 at dry condition and from 150kg/cm2 to 260kg/cm2 at wet condition. The value of elongation was varied within the limits from 7% to 50% at dry condition and from 10% to 65% at wet condition. The rate of biodegradation was very fast at the initial state but it became slow down after 4∼6 days and accessed to the equilibrium state. Water vapor transmission rate and permeability coefficient of Of varied with the change of evaporating time of polyurethane membrane and their values were controlled 6∼1.8(mg/cm2/hr) and [10-7∼10-8cm-73(STP )cm/cm2·sec·cmHg], respectively. Theas values of the bilayer membrane measured in this study were satisfied with those of ideal skin substitute.

표피성분으로는 의료용폴리우레탄을, 진피성분으로는 다공성의 가교화 젤라틴-폴리비닐알코올을 사용하여 이증막을 제조하였다. 인공피부로서 이용가능성을 검토하기 위하여 건조상태와 습윤상태에서의 인장강도 및 신장율, 팽윤도, 생체분해율, 수증기 및 산소투과성을 측정하였다. 가교제의 농도가 증가함에 따라 팽윤도는 감소하였으며, 인장강도는 건조상태에서는 500kg/cm2에서 720kg/cm2까지, 습윤상태에서는 150kg/cm2에서 260kg/cm2까지 증가하였다. 신장율은 건조상태에서는 7%에서 50%까지, 습윤상태에서는 10%에서 65%까지 변화하였다. 생체분해율은 초기에는 매우 빠르게 증가하였으나 4∼6일 이후에는 평형상태고 기의 변화하지 않았다. 폴리우레탄막의 건조시간에 따라 수증기투과율은 6∼1.8(mg/cm2hr), 산소투과계 수는 10-7∼10-8(cm3(STP)cm/cm2·sec·cmHg)으로 변화하였다. 이상의 실험결과로부터 본 연구에서 측정한 이중막의 물성값들은 인공피부를 설계하는 데 있어서 목표값들을 대부분 만족하였다.

Keywords:

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1987; 11(3): 246-253

    Published online Jun 25, 1987

  • 10.7317/pk.
  • Received on Nov 30, -0001
  • Revised on Nov 30, -0001
  • Accepted on Nov 30, -0001

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