Article
  • Preparation and Property of Wet-spun Silk Fibroin Filaments with Fibrils Regenerated by Dissolving in CaCl2-Formic Acid
  • Wu Huiying , Wu Guiying*, Yao Ping, Zhou Yan, Zhang Feng**, and Zuo Baoqi**

  • Suzhou Institute of Trade & Commerce, Suzhou 215009, China
    *Fourth Affiliated Hospital of Inner Mongolia Medical University, Baotou 014030, China
    **National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China

  • CaCl2-포름산 용액에서 재생한 피브릴을 사용한 습식방사 실크 피브로인 필라멘트의 제조 및 특성
Abstract

In this work, silk fibroin (SF) filament with fibrils regenerated by dissolving in CaCl2-formic acid (FA) was prepared by wet-spun method at room temperature. Different from traditional dissolved methods, SF solutions obtained by dissolving in CaCl2-FA preserved fibrils, which have been recognized as the key to the high performance of native silk. The morphology of SF filament was analyzed, very dense filaments with smooth surface and circular, nanofibrils could be observed in longitudinal and cross-sections of filaments. Moreover, the breaking stress of samples was gradually increased with the increase of draw-down ratios. After 3 times drawing, the breaking stress and elongation at break of filament were 276.4±22.6 MPa and 40.8±3.1%, respectively. At the same time, the secondary structure of SF filament was typical β-sheet. In addition, SF filaments showed excellent degradation property, the mass lost of SF filament declined 42% after incubating in protease XIV solution. Above all, the human mesenchymal stem cells (hMSCs) adhered very well on the surface of the filaments, which demonstrated the good biocompatibility of SF filaments, was suitable for application in tissue engineering.


Keywords: silk fibroin fibers, CaCl2-formic acid, fibril, morphology, biomaterials

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2018; 42(5): 721-728

    Published online Sep 25, 2018

  • 10.7317/pk.2018.42.5.721
  • Received on Jan 12, 2018
  • Revised on Mar 15, 2018
  • Accepted on Mar 23, 2018

Correspondence to

  • Wu Huiying
  • Suzhou Institute of Trade & Commerce, Suzhou 215009, China

  • E-mail: why_1220@sina.com