Article
  • Formulation Design of Sustained-release Dosage form of Ticagrelor by Solid Dispersion Using Eudragit RS/RL
  • Byungkwan Moon*, Younghun Lee*, Seung Jae Kim*, Suyoung Been*, Na Eun Kim*, Seong Won Lee*, Sunjae Park*, Jeong Eun Song*, and Gilson Khang*, **, ***,†

  • *Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea
    **Department of Polymer Nano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero,
    Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea

  • Eudragit RS/RL을 이용한 고체분산에 의한 티카그렐러 서방형 제형 설계
  • 문병관* · 이영훈* · 김승재* · 빈수영* · 김나은* · 이성원* · 박선재* · 송정은* · 강길선*, **, ***,†

  • *전북대학교 바이오나노융합공학과, **전북대학교 고분자나노공학과, ***전북대학교 고분자융합소재연구소

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Makki, N.; Brennan, T. M.; Girotra, S. Acute Coronary Syndrome. J. Intensive Care Med. 2015, 30, 186-200.
  •  
  • 2. O’Connor, S. A.; Amour, J.; Mercadier, A.; Martin, R.; Kerneis, M.; Abtan, J.; Brugier, D.; Silvain, J.; Barthelemy, O.; Leprince, P.; Montalescot, G.; Colley, J. P. Efficacy of Ex vivo Autologous and In vivo Platelet Transfusion in the Reversal of P2Y12 Inhibition by Clopidogrel, Prasugrel, and Ticagrelor: The APTITUDE Study. Circ. Cardiovasc. Interv. 2015, 8, e002786.
  •  
  • 3. Franchi, F.; Angiolillo, D. J. Novel Antiplatelet Agents in Acute Coronary Syndrome. Nature Reviews Cardiology 2015, 12, 30-47.
  •  
  • 4. Abbate, R.; Cioni, G.; Ricci, I.; Miranda, M.; Gori, A. M. Thrombosis and Acute Coronary Syndrome. Thromb. Res. 2012, 129, 235-240.
  •  
  • 5. Hao, L., et al., Preparation and In vivo/In vitro Characterization of Ticagrelor PLGA Sustained-release Microspheres for Injection. Des. Monomers Polym. 2021, 24, 305-319.
  •  
  • 6. Kim, B. K.; Hong, S. J.; Cho, Y. H.; Yun, K. H.; Kim, Y. H.; Suh, Y.; Cho, J. Y.; Her, A. Y.; Cho, S.; Jeon, D. W.; Yoo, S. Y.; Cho, D. K.; Hong, B. K.; Kwon, H.; Ahn, C. M.; Shin, D. H.; Nam, C. M.; Kim, J. S.; Ko, Y. G.; Choi, D.; Hong, M. K.; Jang, Y. Effect of Ticagrelor Monotherapy vs Ticagrelor with Aspirin on Major Bleeding and Cardiovascular Events in Patients with Acute Coronary Syndrome: The TICO Randomized Clinical Trial. Jama 2020, 323, 2407-2416.
  •  
  • 7. Kim, S. J.; Lee, H. K.; Na, Y. G.; Bang, K. H.; Lee, H. J.; Wang, M.; Huh, H. W.; Cho, C. W. A Novel Composition of Ticagrelor by Solid Dispersion Technique for Increasing Solubility and Intestinal Permeability. Int. J. Pharm. 2019, 555, 11-18.
  •  
  • 8. Chen, K.; Xia, T.; Shao, D.; Zhou, G.; Shen, J.; Yang, Z. Solubility Measurement and Mathematical Correlation of Ticagrelor in Different Pure Solvents. J. Chem. Eng. Data 2020, 65, 3560-3565.
  •  
  • 9. Na, Y. G.; Byeon, J. J.; Wang, M.; Huh, H. W.; Son, G. H.; Jeon, S. H.; Bang, K. H.; Kim, S. J.; Lee, H. J.; Lee, H. K.; Cho, C. W. Strategic Approach to Developing a Self-microemulsifying Drug Delivery System to Enhance Antiplatelet Activity and Bioavailability of Ticagrelor. Int. J. Nanomedicine 2019, 14, 1193.
  •  
  • 10. Y, J. Y.; Ku, J.; Lee, S. Y.; Kim, B. S.; Kim, M. S.; Lee, B.; Khang, G. S.; Lee, H. B. The Effect of Drug Release from Osmotic Pellet Related to the Various Ratio of Eudragit(R) RL and RS. Polym. Korea 2007, 31, 329-334.
  •  
  • 11. Hancock, B. C.; Parks, M. What is the True Solubility Advantage for Amorphous Pharmaceuticals? Pharm. Res. 2000, 17, 397-404.
  •  
  • 12. Gumieniczek, A.; Berecka-Rycerz, A.; Mroczek, T.; Wojtanowski, K. Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FTIR Methods. Molecules 2019, 24, 4430.
  •  
  • 13. Inam, M.; Wu, J.; Shen, J.; Phan, C. U.; Tang, G.; Hu, X. Preparation and Characterization of Novel Pharmaceutical Co-crystals: Ticagrelor with Nicotinamide. Crystals 2018, 8, 336.
  •  
  • 14. Fan, Z. Q.; Yu, H.; Cai, Y. Q. Determination of Alkyl Ammonium Ionic Liquid Cations by Hydrophilic Interaction Liquid Chromatography and its Application in Analysis of Environmental Water. Anal. Methods 2018, 10, 2812-2820.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(6): 752-756

    Published online Nov 25, 2022

  • 10.7317/pk.2022.46.6.752
  • Received on May 30, 2022
  • Revised on Jul 18, 2022
  • Accepted on Sep 13, 2022

Correspondence to

  • Gilson Khang
  • *Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea
    **Department of Polymer Nano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero,
    Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 Korea

  • E-mail: gskhang@jbnu.ac.kr