Article
  • Preparation and Characterization of Magnetized Microneedles for Magnetic Resonance Molecular Imaging
  • Seung-Jun Lee , Jin-Chul Kim*, and Yong-Min Huh**

  • Process Development Lab., Department of Pharmaceutical Science and Engineering, Seowon University, Chungju, Chungbuk 28674, Korea
    *Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon 24341, Korea
    **Radiology, College of Medicine, Yonsei University, 50-1, Yonsei-Ro, Seodaemun-gu, Seoul 03722, Korea

  • 자기공명분자영상 응용을 위한 자성 마이크로 니들의 제조와 특성분석
  • 이승준 ·김진철* ·허용민**

  • 서원대학교 바이오융합대학 제약공학과 공정개발연구실, *강원대학교 의생명과학대학 생물의소재공학과,
    **연세대학교 의과대학 영상의학교실

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Wang, Y.; Hussain, S.; Krestin, G. Superparamagnetic Iron Oxide Contrast Agents: Physicochemical Characteristics and Applications in MR Imaging. Eur. Radiol. 2001, 11, 2319-2331.
  •  
  • 2. Lee, S. J.; Jeong, J. R.; Shin, S. C.; Chang, Y. H.; Kim, J. D. Nanoparticles of Magnetic Ferric Oxides Encapsulated with PLGA and Their Application as MRI Contrast Agent. J. Magn. Magn. Mater. 2004, 272-276, 2432-2433.
  •  
  • 3. Li, Z.; Chen, H.; Bao, H.; Gao, M. One-Pot Reaction to Synthesize Water-Soluble Magnetite Nanocrystals. J. Am. Chem. Soc. 2004, 16, 1391-1393.
  •  
  • 4. Kim, S. Y.; Oh, J. M.; Lee, J. S.; Kim, T. J.; Choy, J. H. Gadolinium(III) Diethylenetriamine Pentaacetic Acid/Layered Double Hydroxide Nanohybrid as Novel T1-Magnetic Resonant Nanoparticles. J. Nanosci. 2008, 8, 5181-5184.
  •  
  • 5. Sun, G.; Feng, J.; Jing, F.; Pei, F.; Liu, M. Synthesis and Evaluation of Novel Polysaccharide-Gd-DTPA Compounds as Contrast Agent for MRI. J. Magn. Magn. Mater. 2003, 265, 123-129.
  •  
  • 6. Taylor, R. M.; Huber, D. L.; Monson, T. C.; Ali, A. S.; Bisoffi, M.; Sillerud, L. O. Multifunctional Iron Platinum Stealth Immunomicelles: Targeted Detection of Human Prostate Cancer Cells Using Both Fluorescence and Magnetic Resonance Imaging. J. Nanopart. Res. 2011, 13, 4717-4729.
  •  
  • 7. Lee, H. Y.; Lim, N. H.; Seo, J. A.; Khang, G. S.; Kim, J. A.; Lee, H. B.; Cho, S. H. Preparation of Poly(vinylpyrrolidone) Coated Iron Oxide Nanoparticles for Contrast Agent. Polym. Korea 2005, 29, 266-270.
  •  
  • 8. Oh, J. M.; Park, M.; Kim, S. T.; Jung, J. Y.; Kang, Y. G.; Choy, J. H. Efficient Delivery of Anticancer Drug MTX Through MTX-LDH Nanohybrid System. J. Phys. Chem. Solids 2006, 67, 1024-1027.
  •  
  • 9. Kim, J. Y.; Choi, S. J.; Oh, J. M.; Park, T.; Choy, J. H. Anticancer Drug-Inorganic Nanohybrid and Its Cellular Interaction. J. Nanosci. Nanotechnol. 2007, 7, 3700-3705.
  •  
  • 10. Wang, L.; Xing, H.; Zhang, S.; Ren, Q.; Pan, L.; Zhang, K.; Bu, W.; Zheng, X.; Zhou, L.; Peng, W.; Hua, Y.; Shi, J. A Gd-doped Mg-Al-LDH/Au Nanocomposite for CT/MR Bimodal Imagings and Simultaneous Drug Delivery. Biomaterials 2013, 34, 3390-3401.
  •  
  • 11. Lee, S. J.; Jeong, J. R.; Shin, S. C.; Chang, Y. H.; Kim, J. D. Magnetic Enhancement of Iron Oxide Nanoparticles Encapsulated with Poly(d,l-latide-co-glycolide). Colloids Surf., A 2005, 225, 19-25.
  •  
  • 12. Lee, S. J.; Jeong, J. R.; Shin, S. C.; Kim, J. D. Synthesis and Characterization of Superparamagnetic Maghemite Nanoparticles Prepared by Coprecipitation Technique. J. Magn. Magn. Mater. 2004, 282, 147-150.
  •  
  • 13. Lee, S. J.; Kim, H. J.; Huh, Y. M.; Kim, I. W.; Jeong, J. H.; Kim, J. C.; Kim, J. D. Functionalized Magnetic PLGA Nanospheres for Targeting and Bioimaging of Breast Cancer. J. Nanosci. Nanotechnol. 2018, 18, 1542-1547.
  •  
  • 14. Min, H. K.; Kim, J. A.; Kim, J. C.; Lee, S. J. Preparation and Characterization of Superparamagnetic Microneedles (SMMNs) containing Magnetic Cubosome Nanoparticles (MCNs). J. Adv. Eng. Technol. 2019, 12, 103-108.
  •  
  • 15. Lee, S. J. Study of Superparamagnetic Microneedles Containing Iron Oxide Nanoparticles. Appl. Chem. Eng. 2021, 32, 556-561.
  •  
  • 16. Kim, Y. G.; Lee, S. M.; Kim, D. B.; Noh, K. M.; Oh, K. S.; Cho, S. H.; Choi, E. P.; Kim, K. P.; Huh, K. M. Preparation and Characterization of Poly(ethylene glycol)-Doxorubicin/SPION Magnetic Nanoparticles for Cancer Therapy. Polym. Korea 2018, 42, 1059-1067.
  •  
  • 17. Lee, J. H.; Huh, Y. M.; Jun, Y. W.; Seo, J. W.; Jang, J. T.; Song, H. T.; Kim, S.; Cho, E. J.; Yoon, H. G.; Suh, J. S.; Cheon, J. Artificially Engineered Magnetic Nanoparticles for Ultra-Sensitive Molecular Imaging. Nat. Med. 2007, 13, 95-99.
  •  
  • 18. Jun, Y. W.; Huh, Y. M.; Choi, J. S.; Lee, J. H.; Song, H. T.; Kim, S.; Yoon, S.; Kim, K. S.; Shin, J. S.; Suh, J. S.; Cheon, J. Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging. J. Am. Chem. Soc. 2005, 127, 5732-5733.
  •  
  • 19. Lee, J. W.; Choi, S. O.; Felner, E. I.; Prausnitz, M. R. Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone. Small 2011, 7, 531-539.
  •  
  • 20. Han, S. K.; Ha, H. Y.; Lee, S. J. Fabrication of Microneedles Array Combining Biodegradable Hyaluronic Acid and Herbal Medicine Lonicera Flos. Polym. Korea 2019, 43, 540-546.
  •  
  • 21. Han, S. K.; Lee, S. J.; Ha, H. Y. Skin Moisturizing Effects of a Microneedle Patch Containing Hyaluronic Acid and Lonicerae flos. Processes 2021, 9, 321.
  •  
  • 22. Kim, J. A.; Park, S. C.; Alle, M.; Lee, S. J.; Kim; J. C. Magnesium Ascorbyl Phosphate Loaded in Dissolving Stiff Microneedles Containing Cellulose Nanofiber. J. Drug. Deliv. Sci. Technol. 2021, 63, 102439.
  •  
  • 23. Yun, S. K.; Lee, S. J.; Giri, S. S.; Kim, H. J.; Kim, S. G.; Kim, S. W.; Han, S. J.; Kwon, J.; Oh, W. T.; Park, S. C. Vaccination of Fish Against Aeromonas Hydrophila Infections Using the Novel Approach of Transcutaneous Immunization with Dissolving Microneedle Patches in Aquaculture. Fish Shellfish Immunol. 2020, 97, 34-40.
  •  
  • 24. Lee, S. J. Fabrication and Characterization of Micropatterned Elastomeric PDMS Mold. J. Adv. Eng. Technol. 2017, 10, 335-339.
  •  
  • 25. Choi, W. H.; Kim, B. S. Fabrication and Characterization of Dissolving Microneedles Containing Lecithin for Transdermal Drug Delivery. Korean Chem. Eng. Res. 2021, 59, 429-434.
  •  
  • 26. Giudice, E. L.; Campbell, J. D. Needle-Free Vaccine Delivery. Adv. Drug Deliv. Rev. 2006, 58, 68-89.
  •  
  • 27. Ito, Y.; Yoshimura, M.; Tanaka, T.; Takada, K. Effect of Lipophilicity on the Bioavailability of Drugs After Percutaneous Administration by Dissolving Microneedles. J. Pharm. Sci. 2012, 101, 1145-1156.
  •  
  • 28. Sunkavalli, S.; Eedara, B B.; Janga, K. Y.; Velpula, A.; Jukanti, R.; Bandari, S. Preparation and Characterization of Docetaxel Self-Nanoemulsifying Powders (SNEPs): A Strategy for Improved Oral Delivery. Korean J. Chem. Eng. 2016, 33, 1115-1124.
  •  
  • 29. ISO 10993-5:2009(E), Part 5: Tests for In Vitro Cytotoxicity, 8.5 Determination of Cytotoxicity, 3rd ed., 2009.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(6): 783-792

    Published online Nov 25, 2022

  • 10.7317/pk.2022.46.6.783
  • Received on Jul 11, 2022
  • Revised on Aug 29, 2022
  • Accepted on Aug 29, 2022

Correspondence to

  • Seung-Jun Lee
  • Process Development Lab., Department of Pharmaceutical Science and Engineering, Seowon University, Chungju, Chungbuk 28674, Korea

  • E-mail: finedaddy@seowon.ac.kr