Article
  • Synthesis and Characterization of P(AA-co-GelMA) Hydrogel Particles for Oral Protein Drug Delivery Applications

  • Jihwan Oh and Bumsang Kim†

  • Department of Chemical Engineering, Hongik University, Wausanro 94, Mapo-gu, Seoul 04066, Korea

  • 단백질약물의 경구투여용 전달체로 사용하기 위한 P(AA-co-GelMA) 수화젤 입자의 합성 및 평가

  • 오지환 · 김범상†

  • 홍익대학교 화학공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Zhang, Y.; Yang, Z.; Hu, X.; Zhang, L.; Li, F.; Li, M.; Tang, X.; Xiao, W. Development and Evaluation of Mucoadhesive Nanoparticles Based on Thiolated Eudragit for Oral Delivery of Protein Drugs. J. Nanopart. Res. 2015, 17, 98.
  •  
  • 2. Ensign, L. M.; Cone, R.; Hanes, J. Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers. Adv. Drug Deliv. Rev. 2012, 64, 557-570.
  •  
  • 3. Yang, J.; Cho, G.; Lee, T.-G.; Kim, B. pH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for α-MSH Antagonists. AICHE J. 2011, 57, 1919-1925.
  •  
  • 4. Mansuri, S.; Kesharwani, P.; Jain, K.; Tekade, R. K.; Jain, N. K. Mucoadhesion: A Promising Approach in Drug Delivery System. React. Funct. Polym. 2016, 100, 151-172.
  •  
  • 5. Aduba Jr., D. C.; Hammer, J. A.; Yuan, Q.; Yeudall, W. A.; Bowlin, G. L.; Yang, H. Semi-interpenetrating Network (sIPN) Gelatin Nanofiber Scaffolds for Oral Mucosal Drug Delivery. Acta Biomater. 2013, 9, 6576-6584.
  •  
  • 6. Peppas, N. A.; Bures, P.; Leobandung, W.; Ichikawa, H. Hydrogels in Pharmaceutical Formulations. Eur. J. Pharm. Biopharm. 2000, 50, 27-46.
  •  
  • 7. Rosales, A. M.; Anseth, K. S. The Design of Reversible Hydrogels to Capture Extracellular Matrix Dynamics. Nat. Rev. Mater. 2016, 1, 15012.
  •  
  • 8. Langer, R.; Peppas, N. A. Advances in Biomaterials, Drug Delivery, and Bionanotechnology. AICHE J. 2003, 49, 2990-3006.
  •  
  • 9. Lee, S. C.; Kwon, I. K.; Park, K. Hydrogels for Delivery of Bioactive Agents: A Historical Perspective. Adv. Drug Deliv. Rev. 2013, 65, 17-20.
  •  
  • 10. Kim, Y.-H.; Chung, M.; Kim, B. Effect of Polymerization Conditions on the Size Change of Poly(ethylene glycol) Hydrogel Nanoparticles. Korea-Aust. Rheol. J. 2014, 26, 401-404.
  •  
  • 11. Saunders, J. R.; Moussa, W. Dynamic Mechanical Properties and Swelling of UV-photopolymerized Anionic Hydrogels. J. Polym. Sci. Pt. B-Polym. Phys. 2012, 50, 1198-1208.
  •  
  • 12. Lee, E.; Kim, B. Preparation and Characterization of pH-sensitive Hydrogel Microparticles as a Biological on–off Switch. Polym. Bull. 2011, 67, 67-76.
  •  
  • 13. Kim, B.; Lim, S. H.; Ryoo, W. Preparation and Characterization of pH-sensitive Anionic Hydrogel Microparticles for Oral Protein-delivery Applications, J. Biomater. Sci.-Polym. Ed. 2009, 20, 427-436.
  •  
  • 14. Ofokansi, K. C.; Adikwu, M. U.; Okore, V. C. Preparation and Evaluation of Mucin-Gelatin Mucoadhesive Microspheres for Rectal Delivery of Ceftriaxone Sodium. Drug Dev. Ind. Pharm. 2007, 33, 691-700.
  •  
  • 15. Rohrer, J.; Partenhauser, A.; Zupancic, O.; Leonaviciute, G.; Podricnik, S.; Bernkop-Schnurch, A. Thiolated Gelatin Films: Renaissance of Gelatin as Sustained Intraoral Dosage Form. Eur. Polym. J. 2017, 87, 48-59.
  •  
  • 16. Shin, H.; Olsen, B. D.; Khademhosseini, A. The Mechanical Properties and Cytotoxicity of Cell-laden Double-network Hydrogels Based on Photocrosslinkable Gelatin and Gellan Gum Biomacromolecules. Biomaterials 2012, 33, 3143-3152.
  •  
  • 17. Van Den Bulcke, A. I.; Bogdanov, B.; De Rooze, N.; Schacht, E. H.; Cornelissen M.; Berghmans, H. Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels. Biomacromolecules 2000, 1, 31-38.
  •  
  • 18. Wang, J.; Tabata, Y.; Bi, D.; Morimoto, K. Evaluation of Gastric Mucoadhesive Properties of Aminated Gelatin Microspheres. J. Control. Release 2001, 73, 223-231.
  •  
  • 19. Dowding, P. J.; Vincent, B. Suspension Polymerisation to Form Polymer Beads. Colloid Sur. A-Physicochem. Eng. Asp. 2000, 161, 259-269.
  •  
  • 20. Brooks, B. W. Suspension Polymerization Processes. Chem. Eng. Technol. 2010, 33, 1737-1744.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2024; 48(4): 419-425

    Published online Jul 25, 2024

  • 10.7317/pk.2024.48.4.419
  • Received on Apr 12, 2024
  • Revised on Apr 15, 2024
  • Accepted on Apr 18, 2024

Correspondence to

  • Bumsang Kim

  • Department of Chemical Engineering, Hongik University, Wausanro 94, Mapo-gu, Seoul 04066, Korea

  • E-mail: bskim@hongik.ac.kr