Article
  • Releasing Characteristics of Essential Oil from Poly(hydroxyethyl methacrylate) Gel
  • Kong BS, Kim D
  • Poly(hydroxyethyl methacrylate) 겔에서의 정유 방출특성
  • 공배수, 김덕준
Abstract
The releasing behavior of essential oil from a polymer was investigated. Poly(hydroxyethyl methacrylate) (P(HEMA)) hydrogel with varying crosslinking density was synthesized. Eugenol was incorporated into the polymer either by swelling the P(HEMA) gel in the eugenol-dissolved ethanol solution or by adding eugenol during P(HEMA) gel synthesis. After the sample had been dried, absorption of ethanol led the eugenol to release from the swelling matrix to environmental ethanol. The releasing amount of eugenol and its releasing rate were determined using gas chromatography. The diffusion and releasing kinetics of ethanol and eugenol were obtained by analyzing the simple exponent type of time dependent fractional mass release equation. The diffusion coefficient of eugenol was estimated from the experimentally observed oil releasing behavior. The releasing mechanism was influenced by controllerable experimental variables, such as matrix crosslinking density and oil loading method.

고분자 매트릭스로부터 방출되는 정유의 방출거동을 살펴보았다. 고분자 매트릭스로는 Poly(hydroxyethyl methacrylate) (P(HEMA))겔을 HEMA단량체로부터 할성하여 사용하였고 방향제의 기초원료로 많이 이용되는 eugenol을 모델 정유로 사용하였다. Eugenol의 도입은 eugenol을 용매인 에탄올에 녹인 후 고분자 시편에 화산, 침투시킨 후 에탄올을 증발시켜 시편을 건조하거나, P(HEMA) 합성시 eugenol을 첨가함으로써 가능하였다. 에탄올을 화산, 침투시켜 eugenol이 포함된 고분자계를 팽윤시키고 농도구배에 의해 시간에 따라 방출되는 Oil의 양을 가스크포마토그래피를 이용하여 측정, 방출 속도를 결정하였다. Oil과 용매의 확산, 방출기구 및 방출속도론을 고분자 확산연구에서 많이 다루는, 시간에 따른 비질량회산 기본 지수식을 이용하여 해석하였다. Oil의 실험방출거동과 수정 Fick 확산모델을 토대로 oil 투입방법 및 가교제 함량에 따른 oil의 매트릭스내의 농도분포를 예측하고 방출확산계수를 결정하였다.

References
  • 1. Alfrey T, Gurnee EF, Lloyd WG, J. Polym. Sci. C: Polym. Lett., 12, 249 (1961)
  •  
  • 2. Bae YH, Okano T, Ebert C, Heiber S, Dave S, Kim SW, J. Control. Release, 16, 189 (1991)
  •  
  • 3. Kim SW, Bae YH, Okano T, Pharm. Res., 9(3), 283 (1992)
  •  
  • 4. Kim YH, Kim SW, Adv. Drug Delivery Rev., 11, 109 (1993)
  •  
  • 5. Lucht LM, Peppas NA, Chem. Eng. Commun., 30, 291 (1984)
  •  
  • 6. Peppas NAHydrogels in Medicine and Pharmacy, vol. II, Chap. 2, CRC Press, Inc., Boca Raton, FL (1987)
  •  
  • 7. Alger MSMPolymer Science Dictionary, Polytechnic of North London, UK
  •  
  • 8. Ritger PL, Peppas NA, Fuel, 66, 815 (1987)
  •  
  • 9. Cohen MH, Turnbull D, J. Chem. Phys., 31, 1164 (1959)
  •  
  • 10. Fujita H, Fortschr. Hochpolym. Forsch., 3, 1 (1961)
  •  
  • 11. Carnahan B, Luther HA, Wilkes JOApplied Numerical Methods, chap. 7, John Wiley and Sons, New York, NY (1969)
  •  
  • 12. Press WH, Flannery BP, Teukolsky SA, Vetterling WTNumerical Recipes in C, Cambridge University Press, New York, NY (1988)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1996; 20(1): 79-86

    Published online Jan 25, 1996