Article
  • Molecular Conformation of Poly-L-Alanyl-Glycine in Solution
  • Kim KY
  • Poly-L-Alanyl-Glycine의 용액내에서의 분자형태
  • 김계용
Abstract
The random copolymers were obtained by heterogeneous polymerization of glycine N-carboxy anhydride (NCA) and L-alanine NCA in acetonitrile by butylamine as an initiator. In order to investigate the molecular conformation of polymers, the optical rotatory dispersion (ORD) of polymers in dilute solution of dichloroacetic acid (DCA), trifluoroacetic acid (TFA), and chloroform mixture were carried out. The helical content of polymers was calculated from Moffitt''s parameter, b0. Polymers beyond 40 degrees of polymerization, which consist of 10% glycine residue, could form stable helical conformation in DCA. The helical content decreased with the increasing glycine content in the polymer, and the helix breaking action of glycine residue was less than that of D-alanine residue in copolymers containing L-alanine. The assumption was made that the polymers had a random configuration of a block copolymer.

L-alanine NCA와 glycine NCA를 아세토니트릴중에서 부틸아민을 개시제로 불균일계로 중합하여 합성한 poly-L-alanyl-glycine의 용액내에서의 분자형태를 규명하기 위하여 디클로로아세트산(DCA) 및 트리플루오르아세트산(TFA)과 클로로포름 혼합 용매중에서 광회전분산(ORD)을 측정하였다. Moffitt''s parameter b0 로부터 폴리머의 helix 함량을 계산하였다. glycine을 10% 함유한 폴리머는 중합도가 40 이상이면 DCA 중에서 안정한 helix를 형성할 수 있다. helix 함량은 폴리머중의 glycine 함량이 증가할수록 감소하며 glycine 반복단위는 D-alanine 반복단위보다 L-alanine을 함유하는 공중합체중에서 helix를 방해하는 작용이 작았다. 한편, 합성한 폴리머는 블록에 가까운 랜덤의 배열순서를 가진 것으로 간주된다.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1977; 1(5): 231-238

    Published online Jul 25, 1977