Article
  • Photopolymerization and Properties of PCL-Based BiodegradableMolecularly Imprinted Polymers
  • Kim SH, Lee KS, Kim YH, Choi WJ, Kim BS, Kim EK, Kim DS
  • PCL 기반 생분해성 분자 날인 고분자의 광중합 및 물성
  • 김선희, 이경수, 김용훈, 최우진, 김범수, 김응국, 김대수
Abstract
Biodegradable molecularly imprinted polymers (MIPs) can be applied in the biomedical area of biosensors, drug delivery, etc. Therefore, in this study, biodegradable theophylline MIPs were synthesized via photopolymerization using a poly( -caprolactone)(PCL) macromer as a cross-linker and their physical properties were investigated. The yield for the synthesis of the PCL macromer with terminal acrylate groups was ca. 78 mol%. The products were characterized by the combination of FT-IR and 1H-NMR spectroscopic analyses. UV/Visible spectroscopic analysis for removing and rebinding theophylline was performed by monitoring the theophylline concentration in the solution. In vitro biodegradation tests of the theophylline MIPs performed in phosphate buffered saline (PBS) solution at 37 ℃ showed good biodegradability of the MIPs.

생분해성 분자 날인 고분자는 바이오센서, 약물 전달 등의 생의학적 분야에 적용이 가능하다. 그러므로, 본 연구에서는 생분해성 고분자인 poly( -caprolactone)(PCL) 매크로머를 가교제로 사용하여 theophylline 분자 날인 고분자를 광중합을 통해 제조하고 물성을 조사하였다. PCL 매크로머는 말단에 아크릴 기를 갖도록 합성하였으며 FT-IR과 1H-NMR로 확인하였다. PCL 매크로머의 합성수율은 약 78 mol%였다. Theophylline의 제거 및 재결합 실험은 UV/Vis분광기를 이용하여 용액 내 theophylline의 농도를 확인함으로써 이루어졌다. Theophylline 분자 날인 고분자의 생분해성 실험을 37 ℃의 PBS 용액 내에서 진행한 결과 우수한 생분해성을 보였다.

Keywords: biodegradable molecularly imprinted polymers; poly( -caprolactone); theophylline; photopolymerization; biodegradability

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2007; 31(2): 153-159

    Published online Mar 25, 2007

  • Received on Jan 10, 2007
  • Accepted on Mar 15, 2007