Article
  • BCNU Release Behaviour from BCNU/PLGA Wafer Prepared by Vacuum Drying Method
  • Park JS, Shin JH, Lee DH, Rhee JM, Kim MS, Lee HB, Khang G
  • 진공 건조법에 의해 제조된 BCNU/PLGA웨이퍼의 BCNU 방출거동
  • 박정수, 신준현, 이두희, 이종문, 김문석, 이해방, 강길선
Abstract
Biodegradable polymers such as polylactide, polyglycolide and poly(lactide-co-glycolide) (PLGA) have been extensively investigated because of easily controlled drug release rate, completely degradable materials without the toxic by-product, and good biocompatibility. But, according to the bulk erosion property of PLGA in vitro test, it had the disadvantage that first-order release reduced releasing amount slowly after excessive initial burst. In this study, we used PLGA powder obtained through recrystallization to revise bulk erosion property of PLGA. The PLGA used in this study was prepared by vacuum drying method and to estimate release profiles of BCNU loaded PLGA wafer. We also evaluated the release profile of drug with the water soluble additive. It was found that the drug loaded PLGA recrystallized by vacuum drying method exhibited the initial burst and the constant rate of drug release compared to that prepared by a conventional method.

폴리락타이드, 폴리글리콜라이드, 및 글리콜라이드-락타이드 공중합체(PLGA)와 같은 생분해성 고분자들은 쉬운 약물방출량 조절과 부산물독성이 없이 지지체의 완벽한 분해과 좋은 생체적합성을 갖고 있다. 그러나 PLGA는 in vitro 실험에서의 괴상침식, 과도한 초기방출 후의 방출량이 감소하는 단점을 갖고 있다. 본 연구에서 PLGA 재결정 분말은 진공건조법을 이용하여 제조하였으며 1,3-bis(2-chloroethyl)-1-nitro-sourea(BCNU, carmustine)가 함유된 PLGA 웨이퍼의 방출거동을 알아보았으며 동시에 수용성 첨가제를 넣어 약물의 방출거동을 알아보고자 하였다. 진공건조법으로 재결정한 PLGA 웨이퍼가 일반방법으로 제조한 PLGA 웨이퍼보다 수분 흡수율 감소와 웨이퍼 자체 초기의 분해 속도 감소로 인하여 초기 방출량이 감소하고 지속적 방출거동을 가지는 것을 확인하였다.

Keywords: PLGA; morphology; BCNU; biodegradable

References
  • 1. Khang G, Kim MS, Cho SH, Lee I, Rhee JM, Lee HB, Tissue Eng. Regen. Med., 1, 9 (2004)
  •  
  • 2. Jang WY, Kim SH, Lee IW, Kim MS, Rhee JM, Khang G, Lee HB, Tissue Eng. Regen. Med., 2, 100 (2005)
  •  
  • 3. Seo KS, Hong KD, Hyun H, Kim MS, Khang G, Lee HB, Tissue Eng. Regen. Med., 2, 109 (2005)
  •  
  • 4. Kim SK, Hong KD, Kim SH, Kim MS, Khang G, Lee IW, Han CW, Lee HK, Lee HB, Tissue Eng. Regen. Med., 2, 130 (2005)
  •  
  • 5. Miyajima M, Koshika A, Okada J, Kusai A, Ikida M, Int. J. Pharm., 169, 255 (1998)
  •  
  • 6. Choi HS, Kim SW, Yun DI, Khang G, Rhee JM, Kim YS, Lee HB, Polym.(Korea), 25(3), 334 (2001)
  •  
  • 7. Park IK, Oh SH, Lee JH, Tissue Eng. Reg. Med., 1, 164 (2004)
  •  
  • 8. Kim SK, Hong KD, Kim SH, Kim MS, Khang G, Lee I, Lee HK, Lee HB, Tissue Eng. Regen. Med., 2, 130 (2005)
  •  
  • 9. Han CW, Shin YH, Kwon SY, Cho YK, Jo BK, Kim YY, Kim SH, Park KS, Khang G, Tissue Eng. Regen. Med., 2, 123 (2005)
  •  
  • 10. Seong HS, Moon DS, Khang G, Lee HB, Macromol. Chem. Symp., 4, 95 (2001)
  •  
  • 11. Seo SA, Choi HS, Lee DH, Khang G, Lee HB, Polym.(Korea), 25(6), 884 (2001)
  •  
  • 12. Choi HS, Khang G, Shin HC, Rhee JM, Lee HB, Int. J. Pharm., 234, 195 (2002)
  •  
  • 13. Lee JS, Shin JH, Jeong JK, Rhee JM, Lee HB, Khang G, Polym.(Korea), 27(1), 9 (2003)
  •  
  • 14. Khang G, Seo SA, Choi HS, Rhee JM, Lee HB, Macromol. Res., 10(5), 246 (2002)
  •  
  • 15. Khang G, Lee SJ, Lee JH, Kim YS, Lee HB, Bio-Med. Mater. Eng., 9, 179 (1999)
  •  
  • 16. Khang G, Lee HBin Cell-synthetic Surface Interaction: Physicochemical Surface Modification, A. Atala and R. Lanza, Editors, Academic Press, London, pp. 771-797 (2001)
  •  
  • 17. Lee SJ, Khang G, Lee YM, Lee HB, J. Biomater. Sci.-Polym. Ed., 13, 97 (2002)
  •  
  • 18. Khang G, Lee HBBiomedical Polymer, Korean Chemical Society Press, Munundang, Seoul, Korea (2001)
  •  
  • 19. Paoletti P, J. Neurosurg. Sci., 28, 51 (1984)
  •  
  • 20. Seong H, Moon DS, Khang G, Lee JS, Lee HB, Polym.(Korea), 26(1), 128 (2002)
  •  
  • 21. Chae GS, Lee JS, Jeong JK, Cho SH, Lee HB, Khang G, Polym.(Korea), 28(4), 335 (2004)
  •  
  • 22. An TK, Kang HJ, Moon DS, Lee JS, Seong H, Jeong JK, Khang G, Lee HB, Polym.(Korea), 26(5), 670 (2002)
  •  
  • 23. An TK, Kang HJ, Lee JS, Seong H, Jeong JK, Khang G, Hong Y, Lee HB, Polym.(Korea), 26(5), 691 (2002)
  •  
  • 24. Lee JS, An TG, Chae GS, Jeong JK, Cho SH, Lee HB, Khang G, Eur. J. Pharm. Biopharm., 59, 169 (2005)
  •  
  • 25. Seong HS, An TK, Khang G, Choi S, Lee CO, Lee HB, Int. J. Pharm., 251, 1 (2003)
  •  
  • 26. Lee JS, An TK, Shin PK, Chae GS, Jeong JK, Lee B, Cho SH, Khang G, Lee HB, Polym.(Korea), 27(3), 217 (2003)
  •  
  • 27. Cleland JL, Biotechnol. Prog., 14(1), 102 (1998)
  •  
  • 28. Pitt CG, Int. J. Pharm., 59, 173 (1990)
  •  
  • 29. Batycky RP, Hanes J, Langer R, Edwards DA, J. Pharm. Sci., 86, 1464 (1997)
  •  
  • 30. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R, Pharm. Res., 8, 713 (1991)
  •  
  • 31. Kumta PN, Gallet D, Waghray A, Blomgren GE, Setter MP, J. Power Sources, 72(1), 91 (1998)
  •  
  • 32. Guo J, Ping Q, Chen Y, Int. J. Pharm., 216, 17 (2001)
  •  
  • 33. Lee JS, Chae GS, An TK, Khang G, Cho SH, Lee HB, Macromol. Res., 11(3), 183 (2003)
  •  
  • 34. Park EK, Lee SY, Kim TH, Choung PH, Khang G, Son YS, Kim SK, Kim SY, Tissue Eng. Regen. Med., 2, 55 (2005)
  •  
  • 35. Zhang H, Gao S, Int. J. Pharm., 329, 122 (2007)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2007; 31(3): 201-205

    Published online May 25, 2007

  • Received on Jan 24, 2007
  • Accepted on Mar 22, 2007