Article
  • Preparation and Characterization of Self-aggregated Nanoparticles of Chitosan-Lipoic Acid Conjugate
  • Park EJ, Kim YJ
  • 키토산-리포산 자기 조립체의 제조 및 특성
  • 박은주, 김영진
Abstract
The objective of this study is to obtain the anti-oxidant nanoparticles based on biocompatible polymers. It was chosen to conjugate with chitosan as the biodegradable polymer and lipoic acid as the hydrophobic anti-oxidant. Lipoic acid helps the regeneration of exogenous and endogenous anti-oxidants vitamin as well as glutathione and hence acts as antioxidant indirectly. Chitosan was prepared from chitin which was deacetylated under alkali solution for the various reaction time. Lipoic acid-chitosan complex was confirmed by 1H-NMR. The critical aggregation concentration was measured using pyrene and the values were about 5×10^(-3) g/L. The particle shapes and sizes of the chitosan-lipoic acid nanoparticles were about 135 nm that measured by DLS and TEM.

본 연구에서는 키틴의 알칼리 가수분해를 통해 탈아세틸화도가 조절된 세 가지 조건의 키토산을 제조하였고, 이 키토산이 수용성을 지니게 화학적 분해법을 이용해 분자량을 조절하였다. 이렇게 제조된 분자량이 조절된 세 가지 조건의 탈아세틸화도를 가지는 키토산 각각에 항산화제인 리포산을 합성하여 항산화 능력을 가지는 생체 적합성 나노 구조체를 형성하였다. 키토산-리포산의 합성을 확인하기 위하여 분광학적 분석 방법을 사용하여 분석하였다. 키토산-리포산 합성체는 수용액 상태에서 자기조립체를 형성하며 이렇게 형성된 자기조립체 나노 입자는 약 135nm 정도의 크기를 가지고 있음을 알 수 있었다.

Keywords: chitosan; lipoic acid; bioactive ingredient; anti-oxidant; self-aggregated nanoparticles

References
  • 1. Wu XY, Lee PI, J. Appl. Polym. Sci., 77(4), 833 (2000)
  •  
  • 2. Lu JX, Prudhommeaux F, Biomaterials, 20, 1937 (1999)
  •  
  • 3. Park JS, Park JW, Kim BH, Polym.(Korea), 29(2), 183 (2005)
  •  
  • 4. Ramos VM, Rodriguez NM, Rodriguez MS, Heras A, Agullo E, Carbohyd. Polym., 51, 425 (2003)
  •  
  • 5. Jeong MG, Kim DS, Choi YH, Son TW, Kwon OK, Lim HS, Polym.(Korea), 28(3), 253 (2004)
  •  
  • 6. Jang MJ, Kim DG, Jeong YI, Jang MK, Nah JW, Polym.(Korea), 31(6), 555 (2007)
  •  
  • 7. Chung YS, Kim JJ, Choi CY, J. Chitin Chitosan, 10, 202 (2005)
  •  
  • 8. Kim HJ, Jeon DW, J. Kor. Soc. Cloth. Ind., 5, 520 (2003)
  •  
  • 9. Mina S, Miya M, Iwamoto R, Yoshikawa S, J. Appl. Polym. Sci., 28, 1909 (1983)
  •  
  • 10. Lee SH, J. Appl. Polym. Sci., 90(10), 2870 (2003)
  •  
  • 11. Packer L, Witt EH, Tritschler HJ, Free Radic. Biol. Med., 19, 227 (1995)
  •  
  • 12. Lester P, Hans JT, Free Radic. Biol. Med., 20, 625 (1996)
  •  
  • 13. Kim TY, Oh CK, Moon H, Yang JH, J. Korean Ind. Eng. Chem., 6(4), 700 (1995)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2008; 32(6): 544-548

    Published online Nov 25, 2008

  • Received on Jun 3, 2008
  • Accepted on Jul 30, 2008