Article
  • Influence of Water Soluble Polymers on Crystallization of 5-Guanosine Monophosphate
  • Lee MK, Choi HM, Kim WS, Hong JP, Lee JH
  • 구아노신일인산의 결정화에 대한 수용성 고분자의 영향
  • 이민경, 최혜민, 김우식, 홍종팔, 이종휘
Abstract
In presence of a polymer, the crystallization of low MW organic materials can be stopped at an intermediary step, where mesocrystals can be identified. A mesocrystal is defined as a superstructure of nanoparticles having polymer-adsorbed crystal faces on the scale of several hundred nanometers to micrometers. This study examined the effects of water soluble polymers and relevant parameters on the formation of guanosine-5'-monophosphate mesocrystals. It was observed in OM and SEM that GMP obtained in a polymer solution had a unique particle morphology different from the typical one of GMP. XRD analysis indicated that the polymer-directed crystallized GMP had a different polymorph of GMP. This result shows that the crystal structure of GMP can be changed by polymers. It was observed in TGA analysis that the polymer-directed crystallized GMP had a different water content, indicating a different type of hydrate.

고분자를 저분자 유기물질의 결정화 과정에 사용하면 결정형성과정을 중간 단계, 즉 메조크리스탈 단계에서 멈출 수 있다. 메조크리스탈은 수백 나노미터－수 마이크로미터의 결정들이 스스로 배열되어 결정성을 갖는, 결정과 고분자의 복합초구조로 정의할 수 있다. 본 연구에서는 구아노신일인산의 메조크리스탈 형성에서 고분자의 영향과 그와 관련된 변수들에 대해 알아 보았다. OM과 SEM 분석을 통해 고분자유도 결정화에 의한 GMP 결정은 전형적인 GMP입자와는 다른 모폴로지를 보임을 확인하였고, XRD 분석을 통해 새로운 polymorph를 가짐을 확인하였다. 이러한 결과는 고분자에 의해 GMP의 결정구조가 달라졌음을 의미하며, 결정 안에 함유되는 물의 함량이 달라져 다른 수화물 구조를 보임을 TGA 분석을 통해 확인하였다.

Keywords: polymorph; water soluble polymer; guanosine-5'-monophosphate; polymer-directed crystallization; mesocrystal.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2009; 33(2): 124-130

    Published online Mar 25, 2009

  • Received on Sep 12, 2008
  • Accepted on Nov 12, 2008