Article
  • Targeted Drug Delivery Carriers Using Folate Conjugated Poly((R)-3-hydroxy butyrate)-Poly(ethylene glycol) Nanoparticles
  • Kwon SH, Kim YJ
  • Folate가 수식된 Poly((R)-3-hydroxy butyrate)-Poly(ethylene glycol) 나노입자를 이용한 표적지향형 약물전달체
  • 권승호, 김영진
Abstract
Biodegradable poly((R)-3-hydroxy butyrate) and poly(ethylene glycol) was conjugated to make amphiphilic di-block copolymer. Folate was conjugated at di-block copolymer to target the cancer cells. Copolymer was ready to form the self-assembled micelle whose size was 125∼156 nm in aqueous solution. Griseofulvin as a hydrophobic drug was loaded in nanoparticles. Their loading efficiencies were 35∼56%. Hydrophobic drug was continuously released for 24 h. Cell viability test showed that folate attached particles were 10% more efficient than the particles without targeting ligands.

생분해성 고분자인 poly((R)-3-hydroxy butyrate)와 poly(ethylene glycol)을 결합시켜 양친성 이중 블록 공중합체를 형성하였고, 표적인자인 folate를 수식하여 특정 암세포에 표적화하도록 설계하였다. 이 공중합체는 수용액상에서 미셀을 이루며, DLS로 측정한 결과, 125∼156 nm의 크기였고, 동결건조하여 SEM으로 관찰한 결과 구형임을 확인하였다. 여기에 소수성 약물인 griseofulvin을 사용하여, 35∼56%의 봉입률을 나타내었다. 약물은 in vitro 상에서 24시간 동안 지속적으로 방출되었다. 세포생존율을 측정하여, folate가 수식된 입자가 그렇지 않은 입자보다 약 10% 더 낮은 세포생존율을 보임으로써 표적지향 효과가 있다는 것을 알 수 있었다.

Keywords: PHB; PEG; folate; targeting; drug delivery

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2009; 33(6): 515-519

    Published online Nov 25, 2009

  • Received on Sep 3, 2008
  • Accepted on Sep 14, 2009