Article
  • Synthesis, Characterization and Haemocompatibility of Poly(styrene-b-isobutylene-b-styrene) Triblock Copolymers
  • Ren P, Wu YB, Guo WI, Li SX, Mao J, Xiao F, Li K
  • 폴리(스티렌-이소부틸렌-스티렌) 삼중블록 공중합체의 합성, 분석 및 혈액적합성
  • Ren P, Wu YB, Guo WI, Li SX, Mao J, Xiao F, Li K
Abstract
The synthesis of well-defined poly(styrene-b-isobutylene-b-styrene) (SIBS) triblock copolymers was accomplished by cationic sequential block copolymerization of isobutylene (IB) with styrene (St) using 1,4-di(2-chloro-2-propyl)benzene (DCC)/TiCl4 /2,6-di-tert-butylpyridine(DtBP) as an initiating system in methyl chloride (CH3Cl)/methylcyclohexane(MeChx) (50/50 v/v) solvent mixture at -80 ℃. The triblock copolymers exhibited excellent thermoplastic and elastomeric characteristics. Tensile strengths and Shore hardness increased with increasing polystyrene (PS) content, while elongation at break decreased. The blood-compatibility of SIBS was assessed by SEM observation of the platelet adhesion, blood clotting time and haemolysis ratio. The haemolysis ratios were below 5% which met the medical materials standard. The platelet adhesion test further indicated that SIBS block copolymers had a good blood compatibility.

Keywords: poly(styrene-b-isobutylene-b-styrene); haemocompatibility; thermoplastic elastomer; living/controlled cationic polymerization

References
  • 1. Puskas JE, Chen YH, Dahman Y, Padavan D, J.Polym. Sci., Part A: Polym. Chem., 42, 3090 (2004)
  •  
  • 2. El Fray M, Prowans P, Puskas JE, Altstadt V, Biomacromolecules, 7(3), 844 (2006)
  •  
  • 3. Han J, Chen B, Ye L, Zhang AY, Zhang J, Feng ZG, Front. Mater. Sci. China., 3, 25 (2009)
  •  
  • 4. Silva GR, Silva-Cunha A, Behar-Cohen F, Ayres E, Orefice RL, Polym. Degrad. Stabil., 95, 491 (2010)
  •  
  • 5. Kamath KR, Barry JJ, Miller K, Adv. Drug Deliv. Rev., 58, 12 (2006)
  •  
  • 6. Moses J, Serruys PK, Fareed J, Textbook of Inter-Ventional Cardiovascular Pharmacology, Informa Healthcare, London, Boca Raton, FL, Taylor & Francis, p.299 (2007)
  •  
  • 7. Pinchuka L, Wilsonb GJ, Barryc JJ, Schoephoersterd RT, Parele JM, Kennedy JP, Biomaterials., 29, 448 (2008)
  •  
  • 8. Cadieux P, Watterson JD, Denstedt J, Harbottle RR, Puskas J, Howard J, Gan BS, Reid G, Colloids Surf. B., 28, 95 (2003)
  •  
  • 9. Storey RF, Lee YW, J. Macromol. Sci., Part A: Pure Appl. Chem., 29, 1017 (1992)
  •  
  • 10. Storey RF, Baugh DW, Choate KR, Polymer, 40(11), 3083 (1999)
  •  
  • 11. Zhou CR, Yi ZJ, Biomaterials., 20, 2093 (1999)
  •  
  • 12. Ferreira P, Coelho JFJ, Gil MH, Int. J. Pharm., 352, 172 (2008)
  •  
  • 13. Li LH, Tu M, Mou SS, Zhou CR, Biomaterials., 22, 2595 (2001)
  •  
  • 14. Tanaka M, Motomura T, Kawada M, Anzai T, Kasori Y, Shiroya T, Shimura KC, Onishi M, Mochizuki A, Biomaterials., 21, 1471 (2000)
  •  
  • 15. Li LH, Tu M, Mou SS, Zhou CR, Biomaterials., 22, 2595 (2001)
  •  
  • 16. Lee JH, Ju YM, Kim DM, Biomaterials., 21, 683 (2000)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2011; 35(1): 40-46

    Published online Jan 25, 2011

  • Received on Aug 4, 2010
  • Accepted on Oct 21, 2010