• [Communication]
  • Development of Novel Collagen Stimulator Based on Polycaprolactone-poly(ethylene glycol)-polycaprolactone Block Copolymer

  • Hyeon Jin Jeon*, **,† , Woo Sung Lee*, Hak Jin Song*, and Hyung Joo Kim**

  • *R&D Ceneter, ROSELAB Inc, 209 Bongeunsa-ro, Gangnam-gu, Seoul 06109, Korea
    **Department of Biological Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea

  • 폴리카프로락톤-폴리에틸렌글리콜-폴리 카프로락톤 삼중 블록 공중합체 소재 콜라겐 생성 촉진제 개발

  • 전현진*, **,† · 이우성* · 송학진* · 김형주**

  • *㈜로즈랩, R&D센터
    **건국대학교 생물공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Christen, M. O.; Vercesi, F. Polycaprolactone: How a Well-known and Futuristic Polymer has become an Innovative Collagen-stimulator in Esthetics. Clin. Cosmet. Investig. Dermatol., 2020, 31-48.
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  • 2. Melo, F.; Nicolau, P.; Piovano L.; Lin, S. L.; Tiago, B. F.; King, M. Recommendations for Volume Augmentation and Rejuvenation of the Face and Hands with the New Generation Polycaprolactone-based Collagen Stimulator (Ellanse®). Clin Cosmet. Investig. Dermatol., 2017, 431-440.
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  • 3. Lee, S. J.; Lee, W. S.; Chung, C, H. Safety and Efficacy of Polycaprolactone Copolymer Nanosphere Hydrogel Injected into the Scalp Dermal Tissue of Rats. Arch. Aesthetic Plast. Surg., 2019,25, 147-153.
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  • 4. Hong, J. Y.; Kim, J. H.; Kwon, T. R.; Hong, J. K.; Li, K.; Kim, B. J. In vivo Evaluation of Novel Particle-free Polycaprolactone Fillers for Safety, Degradation, and Neocollagenesis in a Rat Model. Dermatol. Ther., 2022, 34, e14770.
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  • 5. Choi, S. Y.; Koh, Y. G.; Yoo, K. H.; Han, H. S.; Seok, J.; Kim B. J. A Randomized, Participant and Evaluator-Blinded, Matched-Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polynucleotide Fillers in the Correction of Crow’s Feet. J. Cosmet. Dermatol., 2024, 24, e16576.
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  • 6. Hyun, H.; Cho, Y. H.; Jeong, S. C.; Lee, B.; Kim, M. S.; Khang, G. S.; Lee, H. B. Synthesis and Characterization of Biodegradable Methoxy Poly(ethylene glycol)-Block Copolymers. Polym. Korea,2006, 30, 28-34.
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  • 7. Seo, K. S.; Park, C. S.; Kim, M. S.; Cho, S. H; Lee, H. B.; Khang, G. S. Thermosensitive Sol-gel Phase Transition Behavior of Methoxy Poly(ethylene glycol)-b-Poly(ε-caprolactone) Diblock Copolymers. Polym. Korea,2004,28, 344-351.
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  • 8. Grossen, P.; Witzigmann, D.; Sieber, S.; Huwyler, J. PEG-PCL-based Nanomedicines: A Biodegradable Drug Delivery System and its Application. J. Controlled Release,2017,260, 46-60.
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  • 9. Nguyen, T. H.; Nguyen, V. C. Formation of Nanoparticles in Aqueous Solution from Poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone). Adv. Nat. Sci. Nanosci. Nanotechnol. 2010, 1, 025012.
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  • 10. Łukasiewicz, S; Mikołajczyk, A; Błasiak, E; Fic, E; D.W, Dziedzicka, M. Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines. Pharmaceutics,2021, 13, 191.
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  • 11. Rabanel, J.M; Hildgen, P; Banquy, X. Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation. J. Control. Release, 2014, 185, 71-87.
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  • 12. Guo, J; Fang, W; Wang, F. Injectable Fillers: Current Status, Physicochemical Properties, Function Mechanism, and Perspectives. RSC. Adv. 2023, 13, 23841-23858.
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  • 13. Kim, J. S. Isovolemic Degradation of Polycaprolactone Particles and Calculation of their Original Size from Human Biopsy. Plast. Reconstr. Surg. Glob. Open, 2020, 8, e2866.
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  • 14. Jiang, Z.; Zhu, Z; Liu, C.; Hu, Y.; Wu, W.; Jiang, X. Non-enzymatic and Enzymatic Degradation of Poly(ethylene glycol)-b-poly(ɛ-caprolactone) Diblock Copolymer Micelles in Aqueous Solution. Polym., 2008, 49, 5513-5519.
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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2025; 49(2): 159-162

    Published online Mar 25, 2025

  • 10.7317/pk.2025.49.2.159
  • Received on Nov 20, 2024
  • Revised on Jan 15, 2025
  • Accepted on Jan 21, 2025

Correspondence to

  • Hyeon Jin Jeon

  • *R&D Ceneter, ROSELAB Inc, 209 Bongeunsa-ro, Gangnam-gu, Seoul 06109, Korea
    **Department of Biological Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea

  • E-mail: jhjwell@roselab.co.kr