• Evaluation of the Survival Rate of Lactobacillus salivarius in the Gastrointestinal Tract According to the Concentration of Alginate Capsules

  • Yeong Kwan Lee* , Wonho Choi*, and Yong-kyu Lee*, **,†

  • *4D Convergence Technology Institute (National Key Technology Institute in University), Korea National University of Transportation, Jungpyeong, Chung-Buk 27909, Korea
    **Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju, Chung-Buk 27469, Korea

  • 알긴산 캡슐의 농도에 따른 위장관에서의 Lactobacillus salivarius 생존율 평가

  • 이영관* · 최원호* · 이용규*, **,†

  • *한국교통대학교 4D 융합기술원, **한국교통대학교 화학생물공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.


References
  • 1. Lee, J. Y.; Tsolis, R. M.; Bäumler, A. J. The Microbiome and Gut Homeostasis. Science. 2022, 377, 6601.
  •  
  • 2. Zeng, W.; Shen, J.; Bo, T.; Peng, L.; Xu, H.; Nasser, M. I.; Zhuang, Q.; Zhao, M. Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation. J. Immunol. Res. Apr 16, 2019, 1603758.
  •  
  • 3. Terri, D.; Boylston, Celso, G.; Vinderola, H. B.; Ghoddusi, J. A. Reinheimer, Incorporation of Bifidobacteria Into Cheeses: Challenges and Rewards. Int. Dairy J., 2004, 14, 375-387.
  •  
  • 4. Naissinger da Silva, M.; Tagliapietra, B. L., et al. In Vitro Test to Evaluate Survival in the Gastrointestinal Tract of Commercial Probiotics. Current Res. Food Sci. 2021, 4, 320-325.
  •  
  • 5. Akbari, A.; Gänzle, M. G.; Wu, J. Cruciferin Improves Stress Resistance and Simulated Gastrointestinal Survival of Probiotic Limosilactobacillus Reuteri in the Model Encapsulation System. Food Hydrocoll. for Health. 2023, 3, 100118.
  •  
  • 6. Okolie, C. L.; Rajendran, S. R.; Udenigwe, C. C.; Aryee, A. N.; Mason, B. Prospects of Brown Seaweed Polysaccharides (BSP) as Prebiotics and Potential Immunomodulators. J. Food Biochem. 2017, 41.
  •  
  • 7. Marinova, V. Y.; Rasheva, I. K.; Kizheva, Y. K.; Dermenzhieva, Y. D.; Hristova, P. K. Microbiological Quality of Probiotic Dietary Supplements. Biotechnol. Biotechnol. Equipment, 2019, 33, 834-841.
  •  
  • 8. Harnsilawat, T.; Pongsawatmanit, R.; McClements, D. J. Characterization of β-Lactoglobulin–Sodium Alginate Interactions in Aqueous Solutions: A Calorimetry, Light Scattering, Electrophoretic Mobility and Solubility Study. Food Hydrocolloids, 2006, 20, 577-585.
  •  
  • 9. Matyash, M.; Despang, F.; Ikonomidou, C.; Gelinsky, M. Swelling and Mechanical Properties of Alginate Hydrogels with Respect to Promotion of Neural Growth. Tissue Eng. Part C Methods. 2014, 20, 401-411.
  •  
  • 10. Afzaal, M.; Khan, A. U.; Saeed, F.; Arshad, M. S.; Khan, M. A.; Saeed, M.; Maan, A. A.; Khan, M. K.; Ismail, Z.; Ahmed, A.; Tufail, T.; Ateeq, H.; Anjum, F. M. Survival and Stability of Free and Encapsulated Probiotic Bacteria Under Simulated Gastrointestinal Conditions and in Ice Cream. Food Sci. Nutrition, 2020, 8, 1649-1656.
  •  
  • 11. Lee, R. J.; Hinson, A.; Bauernschmitt, R.; Matschke K.; Fang Q.; Mann D. L.; Dowling R.; Schiller N.; Sabbah H. N. The Feasibility and Safety of Algisyl-LVRTM as a Method of Left Ventricular Augmentation in Patients with Dilated Cardiomyopathy: Initial First in Man Clinical Results. Int. J. Cardiol. 2015, 199, 18-24.
  •  
  • 12. Messaoudi, S.; Manai, M.; Kergourlay, G.; Prévost, H.; Connil, N.; Chobert, J. M.; Dousset, X. Lactobacillus Salivarius: Bacteriocin and Probiotic Activity. Food Microbiol. 2013, 36, 296-304.
  •  
  • 13. Ocaña, V. S.; Pesce De Ruiz Holgado, A. A.; Nader-Macías, M. E. Characterization of a Bacteriocin-like Substance Produced by a Vaginal Lactobacillus Salivarius Strain. Appl. Environ. Microbiol. 1999, 65, 5631.
  •  
  • 14. Zhuge, A.; Li, B.; Yuan, Y.; Lv, L.; Li, Y.; Wu, J.; Yang, L.; Bian, X.; Wang, K.; Wang, Q.; Yan, R.; Zhu, X.; Li, L. Lactobacillus Salivarius LI01 Encapsulated in Alginate-pectin Microgels Ameliorates D-galactosamine-induced Acute Liver Injury in Rats. Appl. Microbiol. Biotechnol. 2020, 104, 7437-7455.
  •  
  • 15. Pathan, A. K.; Bond, J.; Gaskin, R. E. Sample Preparation for Scanning Electron Microscopy of Plant Surfaces-horses for Courses. Micron. 2008, 39, 1049-1061.
  •  
  • 16. Dezfooli, M.; Masoomi, S.; Gherbezza, J. M. Chitosan-coated Alginate Beads as a Probiotic Delivery System for New Zealand Black-footed Abalone (Haliotis iris). J. Appl. Polym. Sci. 2022, e52626.
  •  
  • 17. Salsac, A. V.; Zang, L.; Gherbezza, J. M. Measurement of Mechanical Properties of Alginate Beads Using Ultrasound. CFM 2009-19 éme Congrés Fraçais de Mécanique, Marseille, France, Aug 24-28, 2009.
  •  
  • 18. Funfakjit, N.; Kanana, N.; Manopakdee, K.; Charnvanich, D. Preparation of Alginate Beads by Ionic Gelation Method Using Encapsulator B-390: Effect of Process Parameters on Physical Properties of Beads. The Thai J. Pharmaceutical Sci. 2024, 48, 5.
  •  
  • 19. Jouki, M.; Khazaei, N.; Rashidi-Alavijeh, S.; Ahmadi, S. Encapsulation of Lactobacillus Casei in Quince Seed Gum-alginate Beads to Produce a Functional Synbiotic Drink Powder by Agro-industrial by-products and Freeze-drying. Food Hydrocolloids. 2021, 120, 106895
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2025; 49(6): 686-692

    Published online Nov 25, 2025

  • 10.7317/pk.2025.49.6.686
  • Received on Jan 22, 2025
  • Revised on Apr 14, 2025
  • Accepted on Apr 22, 2025

Correspondence to

  • Yong-kyu Lee

  • *4D Convergence Technology Institute (National Key Technology Institute in University), Korea National University of Transportation, Jungpyeong, Chung-Buk 27909, Korea
    **Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju, Chung-Buk 27469, Korea

  • E-mail: leeyk@ut.ac.kr