• Modeling of Encapsulation Efficiency for Double Emulsion Process

  • Young Mi Chung†

  • Korea University of Technology and Education, School of Energy, Materials & Chemical Engineering, Chungjeol-ro 1600, Cheonan 31253, Korea

  • 이중유화 공정의 캡슐화 효율에 대한 모델링 연구

  • 정영미†

  • 한국기술교육대학교 에너지신소재화학공학부

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.


References
  • 1. Silva, P. T.; Fries, L. L. M.; de Menezes, C. R.; Holkem, A. T.; Schwan, C. L.; Wigmann, É. F.; Bastos, J. O.; Silva, C. B. Microencapsulation: Concepts, Mechanisms, Methods and Some Applications in Food Technology. Cienc. Rural. 2014, 44, 1304-1311.
  •  
  • 2. Ma, G. Microencapsulation of Protein Drugs for Drug Delivery: Strategy, Preparation, and Applications. J. Control. Release 2014, 193, 324-340.
  •  
  • 3. Yu, J. H.; Jung, I. I.; Lee, J. E.; Lim, G. B. Preparation of Gemcitabine-Loaded Methoxy Poly(ethylene glycol)-b-Poly(L-lactide) Microparticles Using W/O/W Multiple Emulsion Method, KSBB J. 2011, 26, 333-340.
  •  
  • 4. Hong, J. H.; Song, K. S.; Kim, K. J.; Lee, C. S.; Ahn, B. M.; and Kim, B. S. Nano-capsulation of L-Ascorbic Acid in Nonaqueous System. J. Korean Ind. Eng. Chem. 2008, 19, 604-608.
  •  
  • 5. Rasal, R. M.; Janorkar, A. V.; Hirt, D. E. Poly (lactic acid) Modifications. Prog. Polym. Sci. 2010, 35, 338-356.
  •  
  • 6. Popelka, A.; Abdulkareem, A.; Mahmoud, A. A.; Nassr, M. G.; Mohamoud, M. K. A. A.; Mohamoud, K. J.; Hussein, M. K.; Lehocky, M.; Vesela, D.; Humpolíček, P.; Kasak, P. Antimicrobial Modification of PLA Scaffolds with Ascorbic and Fumaric Acids via Plasma Treatment. Surf. Coat. Technol. 2020, 400, 126216.
  •  
  • 7. Carr, A.; Maggini, S. Vitamin C and Immune Function. Nutrients 2017, 9, 1211.
  •  
  • 8. Gęgotek, A.; Skrzydlewska, E. Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid. Antioxidants 2022, 1993.
  •  
  • 9. Mangır, N.; Bullock, A. J.; Roman, S.; Osman, N.; Chapple, C.; MacNeil, S. Production of Ascorbic Acid Releasing Biomaterials for Pelvic Floor Repair. Acta Biomater 2016, 29, 188-197.
  •  
  • 10. Jin, H. R. Generation of Human Cartilage Tissue Using Tissue Engineering. Korean J. Otorhinolaryngol-Head Neck Surg. 2003, 46, 355-363.
  •  
  • 11. Fitzgerald, R.; Bass, L. M.; Goldberg, D. J.; Graivier, M. H.; Lorenc, Z. P. Physiochemical Characteristics of Poly-L-lactic Acid (PLLA). Aesthet Surg J. 2018, 38, 13-17.
  •  
  • 12. Mao, S.; Xu, J.; Cai, C.; Germershaus, O.; Schaper, A.; Kissel, T. Effect of WOW Process Parameters on Morphology and Burst Release of FITC-Dextran Loaded PLGA Microspheres. Int. J. Pharm. 2007, 334, 137-148.
  •  
  • 13. Yang, Y. Morphology, Drug Distribution, and In Vitro Release Profiles of Biodegradable Polymeric Microspheres Containing Protein Fabricated by Double-Emulsion Solvent Extraction/Evaporation Method. Biomaterials 2001, 22, 231-241.
  •  
  • 14. Kim, H. K.; Park, T. G. Comparative Study on Sustained Release of Human Growth Hormone from Semi-Crystalline Poly(l-lactic acid) and Amorphous Poly(d,l-lactic-co-glycolic acid) Microspheres: Morphological Effect on Protein Release. J. Control. Release 2004, 98, 115-125.
  •  
  • 15. Li, Z.; Liu, H.; Zeng, L.; Liu, H.; Yang, S.; Wang, Y. Preparation of High Internal Water-Phase Double Emulsions Stabilized by a Single Anionic Surfactant for Fabricating Interconnecting Porous Polymer Microspheres. Langmuir 2014, 30, 12154-12163.
  •  
  • 16. Arsene, M.-L.; Răut, I.; Călin, M.; Jecu, M.-L.; Doni, M.; Gurban, A.-M. Versatility of Reverse Micelles: From Biomimetic Models to Nano (Bio)Sensor Design. Processes 2021, 9, 345.
  •  
  • 17. Ohwaki, T.; Machida, R.; Ozawa, H.; Kawashima, Y.; Hino, T.; Takeuchi, H.; Niwa, T. Improvement of the Stability of Water-in-oil-in-water Multiple Emulsions by the Addition of Surfactants in the Internal Aqueous Phase of the Emulsions. Int. J. Pharm. 1993, 93, 61-74.
  •  
  • 18. Shim, J.-R.; Hwang, J.-Y.; Park, J.-S.; Chung, Y. M. Process Optimization of PLA Microbead Production. J. Korea Academia-Industrial. 2022, 23, 538-547.
  •  
  • 19. Caritá, A. C.; Fonseca-Santos, B.; Shultz, J. D.; Michniak-Kohn, B.; Chorilli, M.; Leonardi, G. R. Vitamin C: One Compound, Several Uses. Advances for Delivery, Efficiency and Stability. Nanomedicine 2020, 24, 102117.
  •  
  • 20. Rosano, H. L.; Gandolfo, F. G.; Hidrot, J.-D. P. Stability of W1/O/W2 Multiple Emulsions. Colloids Surf. A Physicochem. Eng. Asp. 1998, 138, 109-121.
  •  
  • 21. Muschiolik, G. Multiple Emulsions for Food Use. Curr Opin Colloid Interface Sci. 2007, 12, 213-220.
  •  
  • 22. Sawant, A.; Kamath, S.; KG, H.; Kulyadi, G. P. Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity. AAPS PharmSciTech 2021, 22, 199.
  •  
  • 23. Ohwaki, T.; Nitta, K.; Ozawa, H.; Kawashima, Y.; Hino, T.; Takeuchi, H.; Niwa, T. Improvement of the Formation Percentage of Water-in-oil-in-water Multiple Emulsion by the Addition of Surfactants in the Internal Aqueous Phase of the Emulsion. Int. J. Pharm. 1992, 85, 19-28.
  •  
  • 24. Yun, J. W. Yun; Chung, Y. M. Optimization of Ascorbic Acid Encapsulation in PLA Microcapsules Using Double Emulsion Process. Appl. Chem. Eng. 2024, 35, 115-121.
  •  
  • 25. Maa, Y. F.; Hsu, C. C. Effect of Primary Emulsions on Microsphere Size and Protein-Loading in the Double Emulsion Process, J. Microencapsul. 1997, 14, 225-241.
  •  
  • 26. Zhou, J.; Schutzman, R.; Shi, N-Q.; Ackermann, R.; Olsen, K.; Wang, Y.; Schwendeman, S. P. Influence of Encapsulation Variables on Formation of Leuprolide-loaded PLGA Microspheres. J. Colloid. Interface Sci. 2023, 636, 401-412.
  •  
  • 27. Gander, B.; Merkle, H. P.; Nguyen, V. P.; Ho, N-T. A New Thermodynamic Model to Predict Protein Encapsulation Efficiency in Poly(lactide) Microscopes. J. Phys. Chem. 1995, 99, 16144-16148.
  •  
  • 28. Smith, W. R.; Moucka, F; Nezbeda, I. Osmotic Pressure of Aqueous Electrolyte Solutions via Molecular Simulations of Chemical Potentials: Application to NaCl. Fluid Phase Equilib. 2016, 407, 76-83.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2025; 49(6): 709-718

    Published online Nov 25, 2025

  • 10.7317/pk.2025.49.6.709
  • Received on Mar 4, 2025
  • Revised on Jul 30, 2025
  • Accepted on Sep 1, 2025

Correspondence to

  • Young Mi Chung

  • Korea University of Technology and Education, School of Energy, Materials & Chemical Engineering, Chungjeol-ro 1600, Cheonan 31253, Korea

  • E-mail: quebecoise@koreatech.ac.kr