• Effect of Added Pluronics on Fabrication of Poly(L-lactic acid) Scaffold via Thermally-Induced Phase Separation
  • Kim GE, Kim HD, Lee DS
  • 상 분리법을 이용한 Poly(L-lactic acid) Scaffold 제조에 미치는 Pluronics의 영향
  • 김고은, 김현도, 이두성
Abstract
Regular and highly interconnected macroporous poly(L-lactic acid)(PLLA) scaffolds with pore size of 10~300 μm were fabricated through thermally induced phase separation of PLLA-dioxane-water ternary system in the presence of a small amount of Pluronics. Addition of Pluronics to the ternary system raised the cloud-point temperature curve in the order of P-123
미량의 Pluronics가 첨가된 PLLA/1,4-dioxane/water의 삼성분계상을 온도 변화로 유도된 상 분리법을 이용하여 10~300 μm의 공극 크기를 가지며 공극 간의 연결성이 우수한 PLLA 다공성 지지체를 제조하였다. 순수한 PLLA 용액에 Pluronics를 첨가하면 상 분리 온도가 P-123

Keywords: highly interconnection; Pluronics; PLLA-dioxane-water; PEO block; spinodal region

References
  • 1. Yoo JJ, Lee IWTissue Engineering: Concepts and Applications, ed. by B.J. Choi, p. 26, Korea Medical Publishing Company (1998)
  •  
  • 2. Vacanti CA, Vacanti JPFunction Organ Replacement: The New Technology of Tissue Engineering, ed. by R.L. Tawes, Surgical Technology, London (1991)
  •  
  • 3. Suh H, Polym. Sci. Technol., 10(6), 710 (1999)
  •  
  • 4. Anthony A, Mooney DJ, Vacanti JP, Langer RSynthetic Biodegradable Polymer Scaf-fold, p. 51, Birkauser Press, Boston (1997)
  •  
  • 5. Mikos AG, Sarakinos G, Leite SM, Vacanti JP, Langer R, Biomaterials, 14(5), 323 (1993)
  •  
  • 6. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP, Polymer, 35(5), 1068 (1994)
  •  
  • 7. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R, Biomaterials, 17, 1417 (1996)
  •  
  • 8. Whang K, Thomas CH, Healy KE, Nuber G, Polymer, 36(4), 837 (1995)
  •  
  • 9. Khang G, Jeon JH, Cho JC, Lee HB, Polym.(Korea), 23(3), 471 (1999)
  •  
  • 10. Nam YS, Park TG, J. Biomed. Mater. Res., 47, 8 (1999)
  •  
  • 11. Nam YS, Park TG, Biomaterials, 20, 1783 (1999)
  •  
  • 12. Vandewitte P, Dijkstra PJ, Vandenberg JW, Feijen J, J. Membr. Sci., 117(1-2), 1 (1996)
  •  
  • 13. Olabisi O, Robeson LM, Shaw MTPolymer-Polymer Misibility, Academic Press, Inc., New York (1979)
  •  
  • 14. Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P, Polymer, 37(6), 1027 (1996)
  •  
  • 15. Vandewitte P, Dijkstra PJ, Vandenberg JW, Feijen J, J. Polym. Sci. B: Polym. Phys., 34(15), 2553 (1996)
  •  
  • 16. Hua FJ, Kim GE, Lee DS, J. Biomed. Mater. Res., 63(2), 161 (2002)
  •  
  • 17. Hua FJ, Nam JD, Lee DS, Macromol. Rapid Commun., 22, 1053 (2001)
  •  
  • 18. Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P, J. Biomed. Mater. Res., 30, 449 (1996)
  •  
  • 19. Nace VMNonionic Surfactants, Marcel Dekker, Inc., New York (1996)
  •  
  • 20. Kawakatsu T, Kawasaki K, Furusaka M, Okabayashi H, Kanaya T, J. Chem. Phys., 99(10), 8200 (1993)
  •  
  • 21. Kawakatsu T, Kawasaki K, Furusaka M, Okabayashi H, Kanaya T, J. Chem. Phys., 102(5), 2247 (1995)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2002; 26(6): 821-828

    Published online Nov 25, 2002

  • Received on Sep 2, 2002
  • Accepted on Nov 12, 2002