• Thermosensitive Sol-gel Phase Transition Behavior of Methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) Diblock Copolymers
  • Seo KS, Park CS, Kim MS, Cho SH, Lee HB, Khang G
  • 메톡시 폴리(에틸렌 글리콜)-폴리(ε-카프로락톤) 공중합체의 온도감응성 솔-젤 전이 거동
  • 서광수, 박종수, 김문석, 조선행, 이해방, 강길선
Abstract
Poly(ethylene glycol)-based diblock and triblock polyester copolymers stimulating to temperature were studied as injectable biomaterials in drug delivery system because of their nontoxicity, biocompatibility and biodegradability. We synthesized the diblock copolymers consisting of methoxy poly(ethylene glycol) (MPEG) (Mn=750 g/mole) and poly(ε-caprolactone) (PCL) by ring opening polymerization of ε-CL with MPEG as an initiator in the presence of HCl·Et2O. The aqueous solution of synthesized diblock copolymers represented sol phase at room temperature and a sol to gel phase transition as the temperature increased from room temperature to body temperature. To confirm the in vivo gel formation, we observed the formation of gel in the mice body after injection of 20 wt% aqueous solution of each block copolymer. After 2 months, we observed the maintenance of gel without dispersion in mice. In this study, we synthesized diblock copolymers exhibiting sol-gel phase transition and confirmed the feasibility as biomaterials of injectable implantation.

온도에 반응하는 고분자로서 폴리(에틸렌 글리콜)을 기본으로 다이블록 및 트리블록 폴리에스테르 공중합체들은 비독성과 생체적합성 그리고 생분해성 특징 때문에 주사제형의 약물전달체로서 많은 응용이 이루어지고 있다. 본 연구에서는 다이블록 공중합체를 이용한 새로운 솔-젤 전이 현상을 갖는 고분자를 준비하고자, 평균분자량 750 g/mole의 메톡시 폴리(에틸렌 글리콜)과 카프로락톤을 실온에서 HCl·Et2O존재 하에서 개환중합을 실시하였다. 합성된 고분자는 시차주사열량계와 X-선 회절기를 이용하여 특성을 분석하였고, 수용액상에서의 고분자 용액은 실온에서 신체온도로 온도를 상승시키면 졸에서 겔 상으로의 상변화를 보였다. 신체온도 부근에서의 겔 형성을 확인하기 위하여 20 wt%졸 상태의 고분자 용액을 쥐의 피하에 주입한 결과 분산 없이 겔이 잘 형성되었고 2개월간 겔이 유지됨을 확인하였다. 이러한 연구 결과로, 새로운 솔-겔 상전이 현상을 보이는 다이블록 공중합체를 합성하였고, 주사형 이식 재료로의 가능성을 확인하였다.

Keywords: poly(ethylene glycol); ε-caprolactone; ring opening polymerization; sol-gel transition; injectable implantation

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2004; 28(4): 344-351

    Published online Jul 25, 2004

  • Received on Apr 19, 2004
  • Accepted on Jul 22, 2004